منابع مشابه
CaMKII: New Tricks for an Old Dog
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a pivotal signaling molecule in both the brain and the heart. In this issue of Cell, Erickson et al. (2008) demonstrate a mechanism for CaMKII activation by reactive oxygen species that provides a direct link between kinase activation and cardiac dysfunction.
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Gcn2 was first described in budding yeast as a serine/threonine protein kinase involved in the response to amino acid starvation and this is its best characterized role to date. Recent work has revealed new and exciting roles for Gcn2, which affect many aspects of cellular physiology in response to a number of stresses in addition to starvation. Furthermore, the Gcn2 pathway has been implicated...
متن کاملNew Tricks by an Old Dog
It is generally recognized that the connecting peptide (C-peptide) of proinsulin fulfills an important function in the biosynthesis of insulin. It brings together the A-and B-chains such that the initial folding and interchain disulfide bonds can be formed. Evolutionary considerations suggest that a length of approximately 30 residues for the connecting segment, as is the case for human C-pepti...
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The processing of massive amounts of data on clusters with finite amount of memory has become an important problem facing the parallel/distributed computing community. While MapReduce-style technologies provide an effective means for addressing various problems that fit within the MapReduce paradigm, there are many classes of problems for which this paradigm is ill-suited. In this paper we pres...
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PURPOSE OF REVIEW Antimicrobials are a leading cause of severe T cell-mediated adverse drug reactions (ADRs). The purpose of this review is to address the current understanding of antimicrobial cross-reactivity and the ready availability of and evidence for in-vitro, in-vivo, and ex-vivo diagnostics for T cell-mediated ADRs. RECENT FINDINGS Recent literature has evaluated the efficacy of trad...
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ژورنال
عنوان ژورنال: Current Opinion in Infectious Diseases
سال: 2016
ISSN: 0951-7375
DOI: 10.1097/qco.0000000000000323